Ephys & fMRI

Name: Ephys & fMRI
Brand: TDT

Record real-time spikes and LFPs during fMRI scans

Overview

Combining electrophysiology with functional MRI provides a more intricate picture of brain activity by correlating the BOLD signal with neural responses. TDT has engineered a complete solution for concurrent recordings during fMRI imaging [doi.org/10.7554]:

Large Input Range: Our amplifiers have a +/-500 mV input range to capture scanner artifacts without saturating
High Dynamic Range: 124 dB dynamic range preserves neural signal fidelity alongside massive scanner artifacts
Non-Ferrous Headstages: 16 and 32 channel MRI-compatible headstages minimize imaging artifacts
Real-Time Artifact Rejection: The MRI Recording Processor gizmo in Synapse provides real-time visualization of spikes and LFPs during scans
DC-Coupled Amplification: Minimizes signal distortion for better artifact removal

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Pre-configured systems

Starting points our application scientists recommend. Every setup can be changed or expanded; tell us about your experiment and we will adapt it.

Complete 32 Channel FMRI System

A standalone RZ5D processor with Subject Interface designed for fMRI-compatible electrophysiology. Comes with an MRI recording kit with RF filters, non-ferrous headstage extension cables, and more. The large input range of the Subject Interface captures scanner artifacts without signal saturation, enabling artifact removal and recovery of neural signals during simultaneous fMRI and electrophysiology recordings.

Includes

RZ5D Base Processor
RZ5D Base ProcessorThe RZ5 platform features two or three ultra fast digital signal processors networked on a novel bus architecture that speeds both onboard…View product page →
PZ5 Flexible Amplifiers
PZ5 Flexible AmplifiersTDT provides integrated software and hardware solutions for any type of physiological recording.View product page →
Omnetics Chronic Headstages
Omnetics Chronic HeadstagesThe RA16CH is a 16-channel headstage featuring a female Omnetics nano connector.View product page →

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Concurrent Ephys and MRI imaging system

TDT provides a simple connection between the animal in the scanner and our recording system. Our MRI-compatible headstages connect to an RF filter on the back of the PZ amplifier to minimize artifacts from electromagnetic noise and ferrous components.

The PZ5 does the heavy lifting with its large input range and excellent signal-to-noise for recording ephys. Last but not least, the real-time RZ processor provides the perfect solution for real-time visualization of your neural signals.

PZ5 Amplifier

The core of TDT’s solution is the PZ5 amplifier. This analog amplifier has a large input range (500 mVolts) and excellent signal resolution (<250 nanoVolts). This ensures perfect signal fidelity during the MRI scan with no signal saturation.

Combined with TDT’s real-time signal processor (RZ5D or RZ2), the PZ5 is an optimal solution for concurrent ephys and fMRI.

NON-FERROUS HARDWARE

16 and 32 ch MRI-compatible headstages

The TDT MRI-compatible headstages are non-ferrous to minimize electromagnetic interference in the scanner. The small form factor of our 16 and 32 channel Omnetics-based headstages fit easily into small bore MRIs for rodents and marmosets; and our extra-long cables ensure that only the headstage is in the MRI room.

MRI Kit

The MRI kit contains RF filters, cable extenders and test resistors that augment our MRI-compatible headstages. Includes:

RF filters that minimize EMF artifacts on your fMRI scans
Cable extenders that maintain proper distance between the scanner and amplifier without reduced signal quality
Test resistors for measuring electrical noise in the MRI

MRI compatible Non-ferrous HeadstageHeadstages for Primate and Rodent work

Real-time MRI artifact rejection

This Gizmo provides users with real-time artifact removal of the MRI scan for visualization of neural activity, such as LFPs and spiking activity. Use the Gizmo to:

Control the artifact threshold and size of the artifact window

Set a threshold for artifact removal

Save the raw data for offline analysis and artifact subtraction