Fiber Photometry System
Perform Three-Color Photometry with the iX7
Description
Specs & Resources
Publications
Fiber Photometry is a recording technique that uses low-powered light from LEDs to detect calcium or neurotransmitter activity in cell populations via genetically encoded fluorescent indicators (GEFIs) [10.1016/j.neuron.2023.11.016]. Neurons, glial cells, and astrocytes can be targeted with viral vectors so that only specific receptor types express fluorescent proteins. This localization and easy chronic recording setup makes fiber photometry a great choice for studying the roles of select brain nuclei and neurotransmitters in behavioral assays.
TDT is the long-time industry leader in fiber photometry.
Our turn-key optical solutions have been used by researchers to pioneer the field of fiber photometry. Our lock-in amplifier systems are proven to be the most sensitive and versatile systems on the market.
2022 * RZ10X
* Goldstein, … Betley, et al. (2022). “Specificity of Varenicline in Blocking Mesolimbic Circuit Activation to Natural and Drug Rewards”. Neuroscience, 483. https://doi.org/10.1016/J.NEUROSCIENCE.2021.12.016
Liu, … Anderson, et al. (2022). “Make war not love: The neural substrate underlying a state-dependent switch in female social behavior”. Neuron. https://doi.org/10.1016/j.neuron.2021.12.002
Wu, … Halpern, et al. (2022). “Local accumbens in vivo imaging during deep brain stimulation reveals a strategy-dependent amelioration of hedonic feeding”. Proceedings of the National Academy of Sciences, 119(1). https://doi.org/10.1073/pnas.2109269118
2021 * RZ10X
* Copits, … Bruchas, et al. (2021). “A photoswitchable GPCR-based opsin for presynaptic inhibition”. Neuron, 109(11). https://doi.org/10.1016/J.NEURON.2021.04.026
* Ferrara, … Rosenkranz, et al. (2021). “Developmental Shifts in Amygdala Activity during a High Social Drive State”. Journal of Neuroscience, 41(45). https://doi.org/10.1523/JNEUROSCI.1414-21.2021
* Horio, Liberles. (2021) “Hunger enhances food-odour attraction through a neuropeptide Y spotlight”. Nature, 592(7853). https://doi.org/10.1038/s41586-021-03299-4
Samineni, … Gereau, et al. (2021). “Cellular, circuit and transcriptional framework for modulation of itch in the central amygdala”. ELife, 10. https://doi.org/10.7554/eLife.68130
Robert, … Polley, et al. (2021). “A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes”. ELife, 10. https://doi.org/10.7554/eLife.69514
Reichenbach, … Andrews, et al. (2021). “Glucose-sensing in AgRP neurons integrates homeostatic energy state with dopamine signalling in the striatum”. BioRxiv. https://doi.org/10.1101/2021.03.22.436393
Tian, … Beier, et al. (2021). “An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement”. BioRxiv. https://doi.org/10.1101/2021.11.05.467532
Chiacchierini, … McCutcheon, et al. (2021). “Protein Appetite Drives Macronutrient-Related Differences in Ventral Tegmental Area Neural Activity”. The Journal of Neuroscience, 41(23). https://doi.org/10.1523/JNEUROSCI.3082-20.2021
Choi, … McNally, et al. (2021). “A corticothalamic circuit trades off speed for safety during decision-making under motivational conflict”. BioRxiv. https://doi.org/10.1101/2021.11.21.469477
Feng, … He, et al. (2021). “The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the lateral amygdala via cholecystokinin”. BioRxiv. https://doi.org/10.1101/2021.04.18.440346
Penzo, … Chudasama, et al. (2021). “Divergent projections of the paraventricular nucleus of the thalamus mediate the selection of reactive and proactive defensive behaviors”. Research Square. https://doi.org/10.21203/rs.3.rs-322756/v1
Ghareh, … Marchant, et al. (2021). “Role of anterior insula cortex in context-induced relapse of nicotine-seeking”. BioRxiv. https://doi.org/10.1101/2021.12.08.471717
Holly, … Fuccillo, et al. (2021). “Striatal low-threshold spiking interneurons locally gate dopamine”. Current Biology, 31(18). https://doi.org/10.1016/J.CUB.2021.06.081
Wang, … Pitt, et al. (2021). “Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors”. JCI Insight, 6(15). https://doi.org/10.1172/jci.insight.150698
Luchsinger, … Centanni, et al. (2021). “Delineation of an insula-BNST circuit engaged by struggling behavior that regulates avoidance in mice”. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-23674-z
van Zessen, … Lüscher, et al. (2021). “Dynamic dichotomy of accumbal population activity underlies cocaine sensitization”. ELife, 10. https://doi.org/10.7554/eLife.66048
McGovern, … Root, et al. (2021). “Neurochemical Signaling of Reward and Aversion to Ventral Tegmental Area Glutamate Neurons”. The Journal of Neuroscience, 41(25). https://doi.org/10.1523/JNEUROSCI.1419-20.2021
Yau, … McNally, et al. (2021). “The Roles of Basolateral Amygdala Parvalbumin Neurons in Fear Learning”. The Journal of Neuroscience, 41(44). https://doi.org/10.1523/JNEUROSCI.2461-20.2021
Melchior, … Winder, et al. (2021). “Cocaine Augments Dopamine-Mediated Inhibition of Neuronal Activity in the Dorsal Bed Nucleus of the Stria Terminalis”. Journal of Neuroscience, 41(27). https://doi.org/10.1523/JNEUROSCI.0284-21.2021
Smiley, … Gass, et al. (2021). “Adolescent exposure to delta-9-tetrahydrocannabinol and ethanol heightens sensitivity to fear stimuli”. Behavioural Brain Research, 415. https://doi.org/10.1016/J.BBR.2021.113517
Zhang, … Ma, et al. (2021). “Ventral striatal islands of Calleja neurons control grooming in mice”. Nature Neuroscience, 24(12). https://doi.org/10.1038/s41593-021-00952-z
Thirtamara Rajamani, … Harony-Nicolas, et al. (2021). “Efficiency of cell-type specific and generic promoters in transducing oxytocin neurons and monitoring their neural activity during lactation”. Scientific Reports 2021 11:1, 11(1). https://doi.org/10.1038/s41598-021-01818-x
Martyniuk, … Kellendonk, et al. (2021). “Dopamine D2Rs Coordinate Cue-Evoked Changes in Striatal Acetylcholine Levels”. BioRxiv. https://doi.org/10.1101/2021.12.08.471871
He, … Xu, et al. (2021). “5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding”. Molecular Psychiatry. https://doi.org/10.1038/s41380-021-01220-z
Jung, … Kim, et al. (2021). “A forebrain neural substrate for behavioral thermoregulation”. Neuron. https://doi.org/10.1016/j.neuron.2021.09.039
Jean-Richard-dit-Bressel, … McNally, et al. (2021). “Instrumental aversion coding in the basolateral amygdala and its reversion by a benzodiazepine”. Neuropsychopharmacology 2021. https://doi.org/10.1038/s41386-021-01176-2
Froemke, … Jung, et al. (2021). “Neural circuitry for maternal oxytocin release induced by infant cries”. Research Square. https://doi.org/10.21203/rs.3.rs-970204/v1
Kutlu, … Calipari, et al. (2021). “Dopamine release in the nucleus accumbens core signals perceived saliency”. Current Biology, 31(21). https://doi.org/10.1016/j.cub.2021.08.052
Goldstein, … Alhadeff, et al. (2021). “Hypothalamic detection of macronutrients via multiple gut-brain pathways”. Cell Metabolism, 33(3). https://doi.org/10.1016/j.cmet.2020.12.018
Spring, … Wheeler, et al. (2021). “Chronic Stress Prevents Cortico-Accumbens Cue Encoding and Alters Conditioned Approach”. The Journal of Neuroscience, 41(11). https://doi.org/10.1523/JNEUROSCI.1869-20.2021
Dong, … Williams, et al. (2021). “Time and metabolic state-dependent effects of GLP-1R agonists on NPY/AgRP and POMC neuronal activity in vivo”. Molecular Metabolism, 54. https://doi.org/10.1016/j.molmet.2021.101352
Park, … Kim, et al. (2021). “Social isolation impairs the prefrontal-nucleus accumbens circuit subserving social recognition in mice”. Cell Reports, 35(6). https://doi.org/10.1016/j.celrep.2021.109104
He, … Xu, et al. (2021). “Barbadin Potentiates Long-Term Effects of Lorcaserin on POMC Neurons and Weight Loss”. The Journal of Neuroscience, 41(26). https://doi.org/10.1523/JNEUROSCI.3210-20.2021
Norman, … Morishita, et al. (2021). “Post-error recruitment of frontal sensory cortical projections promotes attention in mice”. Neuron, 109. https://doi.org/10.1016/j.neuron.2021.02.001
Sherathiya, … Lerner, et al. (2021). “GuPPy, a Python toolbox for the analysis of fiber photometry data”. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-03626-9
de Kloet … Mansvelder, et al “Bi-directional regulation of cognitive control by distinct prefrontal cortical output neurons to thalamus and striatum”. Nature Communications Mar, 2021. doi: 10.1038/s41467-021-22260-7
Stern … Friedman, et al “Top-down control of conditioned overconsumption is mediated by insular cortex Nos1 neurons”. Cell Metabolism Mar, 2021. doi: 10.1016/j.cmet.2021.03.001
Peters … McCutcheon, et al “Distracting stimuli evoke ventral tegmental area responses in rats during ongoing saccharin consumption”. European Journal of Neuroscience Mar, 2021. doi: 10.1111/ejn.15108
Sathyanesan … Gallo, et al “Disruption of neonatal Purkinje cell function underlies injury-related learning deficits”. Proceedings of the National Academy of Sciences Mar, 2021. doi: 10.1073/pnas.2017876118
Bruno … Barker, et al “pMAT: An open-source software suite for the analysis of fiber photometry data”. Pharmacology Biochemistry and Behavior Feb, 2021. doi: 10.1016/j.pbb.2020.173093
Mayer … Blakely, et al “There’s no place like home? Return to the home cage triggers dopamine release in the mouse nucleus accumbens”. Neurochemistry International Jan, 2021. doi: 10.1016/j.neuint.2020.104894
Karigo … Anderson, et al “Distinct hypothalamic control of same- and opposite-sex mounting behaviour in mice”. Nature Jan, 2021. doi: 10.1038/s41586-020-2995-0
2020
Seiler, … Lerner, et al. (2020). “Dopamine signaling in the dorsomedial striatum promotes compulsive behavior”. BioRxiv. https://doi.org/10.1101/2020.03.30.016238
Alabi, … Fuccillo, et al. (2020). “Disruption of Nrxn1α within excitatory forebrain circuits drives value-based dysfunction”. ELife, 9. https://doi.org/10.7554/eLife.54838
Sofia Beas … Penzo, et al “A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding”. Nature Communications Dec, 2020. doi: 10.1038/s41467-020-19980-7
He … Xu, et al “Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance”. Nature Communications Dec, 2020. doi: 10.1038/s41467-020-15982-7
Hsu … Roitman, et al “Thirst recruits phasic dopamine signaling through subfornical organ neurons”. Proceedings of the National Academy of Sciences Dec, 2020. doi: 10.1073/pnas.2009233117
Bicks … Morishita, et al “Prefrontal parvalbumin interneurons require juvenile social experience to establish adult social behavior”. Nature Communications Dec, 2020. doi: 10.1038/s41467-020-14740-z
Jaramillo … Centanni, et al “BNST transient activity associates with approach behavior in a stressful environment and is modulated by the parabrachial nucleus”. Neurobiology of Stress Nov, 2020. doi: 10.1016/j.ynstr.2020.100247
Miletta … Horvath, et al “AgRP neurons control compulsive exercise and survival in an activity-based anorexia model”. Nature Metabolism Nov, 2020. doi: 10.1038/s42255-020-00300-8
Yamamuro … Morishita, et al “A prefrontal–paraventricular thalamus circuit requires juvenile social experience to regulate adult sociability in mice”. Nature Neuroscience Oct, 2020. doi: 10.1038/s41593-020-0695-6
Root … Morales, et al “Distinct Signaling by Ventral Tegmental Area Glutamate, GABA, and Combinatorial Glutamate-GABA Neurons in Motivated Behavior”. Cell Reports Sep, 2020. doi: 10.1016/j.celrep.2020.108094
Liu … McNally, et al “The Mesolimbic Dopamine Activity Signatures of Relapse to Alcohol-Seeking”. The Journal of Neuroscience Aug, 2020. doi: 10.1523/jneurosci.0724-20.2020
Barbano … Morales, et al “VTA Glutamatergic Neurons Mediate Innate Defensive Behaviors”. Neuron Jul, 2020. doi: 10.1016/j.neuron.2020.04.024
Cho … Sohal, et al “Cross-hemispheric gamma synchrony between prefrontal parvalbumin interneurons supports behavioral adaptation during rule shift learning”. Nature Neuroscience Jul, 2020. doi: 10.1038/s41593-020-0647-1
Gadziola … Wesson, et al “A Neural System that Represents the Association of Odors with Rewarded Outcomes and Promotes Behavioral Engagement”. Cell Reports Jul, 2020. doi: 10.1016/j.celrep.2020.107919
Jacobs, Moghaddam “Prefrontal Cortex Representation of Learning of Punishment Probability During Reward-Motivated Actions”. The Journal of Neuroscience Jun, 2020. doi: 10.1523/jneurosci.0310-20.2020
Steinberg … Malenka, et al “Amygdala-Midbrain Connections Modulate Appetitive and Aversive Learning”. Neuron Jun, 2020. doi: 10.1016/j.neuron.2020.03.016
Salimando … Winder, et al “BNST GluN2D-Containing NMDA Receptors Influence Anxiety- and Depressive-like Behaviors and ModulateCell-Specific Excitatory/Inhibitory Synaptic Balance”. The Journal of Neuroscience May, 2020. doi: 10.1523/jneurosci.0270-20.2020
Tan … Zuker, et al “The gut–brain axis mediates sugar preference”. Nature Apr, 2020. doi: 10.1038/s41586-020-2199-7
Berland … Luquet, et al “Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons”. Cell Metabolism Apr, 2020. doi: 10.1016/j.cmet.2020.02.010
Lafferty … Britt, et al “Nucleus Accumbens Cell Type- and Input-Specific Suppression of Unproductive Reward Seeking”. Cell Reports Mar, 2020. doi: 10.1016/j.celrep.2020.02.095
Pignatelli … Bonci, et al “Cooperative synaptic and intrinsic plasticity in a disynaptic limbic circuit drive stress-induced anhedonia and passive coping in mice”. Molecular Psychiatry Mar, 2020. doi: 10.1038/s41380-020-0686-8
Corkrum … Araque, et al “Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity”. Neuron Mar, 2020. doi: 10.1016/j.neuron.2019.12.026
Konanur … Roitman, et al “Phasic dopamine responses to a food-predictive cue are suppressed by the glucagon-like peptide-1 receptor agonist Exendin-4”. Physiology & Behavior Mar, 2020. doi: 10.1016/j.physbeh.2019.112771
Marcus … Patel, et al “Endocannabinoid Signaling Collapse Mediates Stress-Induced Amygdalo-Cortical Strengthening”. Neuron Mar, 2020. doi: 10.1016/j.neuron.2019.12.024
Gao … Penzo, et al “Two genetically, anatomically and functionally distinct cell types segregate across anteroposterior axis of paraventricular thalamus”. Nature Neuroscience Feb, 2020. doi: 10.1038/s41593-019-0572-3
Salimando … Winder, et al “BNST GluN2D-Containing NMDA Receptors Influence Anxiety-and Depressive-like Behaviors and Modulate Cell-Specific Excitatory/Inhibitory Synaptic Balance”. The Journal of Neuroscience , 2020. doi: 10.1523/jneurosci.0270-20.2020
2019
Heifets … Malenka, et al “Distinct neural mechanisms for the prosocial and rewarding properties of MDMA”. Science Translational Medicine Dec, 2019. doi: 10.1126/scitranslmed.aaw6435
Mendoza … Britt, et al “Cue-Evoked Dopamine Neuron Activity Helps Maintain but Does Not Encode Expected Value”. Cell Reports Nov, 2019. doi: 10.1016/j.celrep.2019.09.077
Alhadeff … Betley, et al “Natural and Drug Rewards Engage Distinct Pathways that Converge on Coordinated Hypothalamic and Reward Circuits”. Neuron Sep, 2019. doi: 10.1016/j.neuron.2019.05.050
Shi … Fu, et al “A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors”. Neuron Sep, 2019. doi: 10.1016/j.neuron.2019.07.026
Sengupta, Holmes “A Discrete Dorsal Raphe to Basal Amygdala 5-HT Circuit Calibrates Aversive Memory”. Neuron Aug, 2019. doi: 10.1016/j.neuron.2019.05.029
Guo … Polley, et al “The Cholinergic Basal Forebrain Links Auditory Stimuli with Delayed Reinforcement to Support Learning”. Neuron Jul, 2019. doi: 10.1016/j.neuron.2019.06.024
Parker … Bruchas, et al “A Paranigral VTA Nociceptin Circuit that Constrains Motivation for Reward”. Cell Jul, 2019. doi: 10.1016/j.cell.2019.06.034
Choi … McNally, et al “Paraventricular Thalamus Controls Behavior during Motivational Conflict”. The Journal of Neuroscience Jun, 2019. doi: 10.1523/jneurosci.2480-18.2019
Feng … Li, et al “A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine”. Neuron May, 2019. doi: 10.1016/j.neuron.2019.02.037
Cameron … Witten, et al “Increased Cocaine Motivation Is Associated with Degraded Spatial and Temporal Representations in IL-NAc Neurons”. Neuron May, 2019. doi: 10.1016/j.neuron.2019.04.015
Mansy … Oweiss, et al “Spatial detection characteristics of a single photon fiber photometry system for imaging neural ensembles *”. 2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) Mar, 2019. doi: 10.1109/ner.2019.8717005
Zimmer … Dietrich, et al “Functional Ontogeny of Hypothalamic Agrp Neurons in Neonatal Mouse Behaviors”. Cell , 2019. doi: 10.1016/j.cell.2019.04.026
Holly … Fuccillo, et al “Striatal Low-Threshold Spiking Interneurons Regulate Goal-Directed Learning”. Neuron , 2019. doi: 10.1016/j.neuron.2019.04.016
Li … Krashes, et al “Defined Paraventricular Hypothalamic Populations Exhibit Differential Responses to Food Contingent on Caloric State”. Cell Metabolism , 2019. doi: 10.1016/j.cmet.2018.10.016
Robinson … Gradinaru, et al “Optical dopamine monitoring with dLight1 reveals mesolimbic phenotypes in a mouse model of neurofibromatosis type 1”. eLife , 2019. doi: 10.7554/elife.48983
Bai … Knight, et al “Genetic Identification of Vagal Sensory Neurons That Control Feeding.”. Cell , 2019. doi: 10.1016/j.cell.2019.10.031
2018
Pascoli … Lüscher, et al “Stochastic synaptic plasticity underlying compulsion in a model of addiction”. Nature Dec, 2018. doi: 10.1038/s41586-018-0789-4
Reed … Britt, et al “Coordinated Reductions in Excitatory Input to the Nucleus Accumbens Underlie Food Consumption”. Neuron Sep, 2018. doi: 10.1016/j.neuron.2018.07.051
Walsh … Malenka, et al “5-HT release in nucleus accumbens rescues social deficits in mouse autism model”. Nature Aug, 2018. doi: 10.1038/s41586-018-0416-4
Saunders … Janak, et al “Dopamine neurons create Pavlovian conditioned stimuli with circuit-defined motivational properties”. Nature Neuroscience Jul, 2018. doi: 10.1038/s41593-018-0191-4
Giza … Lee, et al “The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior”. Neuron Jul, 2018. doi: 10.1016/j.neuron.2018.05.024
Beas … Penzo, et al “The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism”. Nature Neuroscience Jun, 2018. doi: 10.1038/s41593-018-0167-4
Fang … Lin, et al “A Hypothalamic Midbrain Pathway Essential for Driving Maternal Behaviors”. Neuron Apr, 2018. doi: 10.1016/j.neuron.2018.02.019
Sengupta … McNally, et al “Basolateral Amygdala Neurons Maintain Aversive Emotional Salience”. The Journal of Neuroscience Mar, 2018. doi: 10.1523/jneurosci.2460-17.2017
Augustine … Oka, et al “Hierarchical neural architecture underlying thirst regulation”. Nature Mar, 2018. doi: 10.1038/nature25488
Wang … Krauzlis, et al “Activation of Striatal Neurons Causes a Perceptual Decision Bias during Visual Change Detection in Mice”. Neuron Mar, 2018. doi: 10.1016/j.neuron.2018.01.049
Chen … Dan, et al “A Hypothalamic Switch for REM and Non-REM Sleep”. Neuron Mar, 2018. doi: 10.1016/j.neuron.2018.02.005
2017
Hashikawa … Lin, et al “Esr1+ cells in the ventromedial hypothalamus control female aggression”. Nature Neuroscience Nov, 2017. doi: 10.1038/nn.4644
Barker … Morales, et al “Lateral Preoptic Control of the Lateral Habenula through Convergent Glutamate and GABA Transmission”. Cell Reports Nov, 2017. doi: 10.1016/j.celrep.2017.10.066
Calipari … Nestler, et al “Dopaminergic dynamics underlying sex-specific cocaine reward”. Nature Communications Apr, 2017. doi: 10.1038/ncomms13877
2016
Wells … Halassa, et al “Thalamic reticular impairment underlies attention deficit in Ptchd1Y/− mice”. Nature Mar, 2016. doi: 10.1038/nature17427
Zalocusky … Deisseroth, et al “Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making”. Nature Mar, 2016. doi: 10.1038/nature17400
Calipari … Nestler, et al “In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward”. Proceedings of the National Academy of Sciences of the United States of America , 2016. doi: 10.1073/pnas.1521238113
2015
Wimmer … Halassa, et al “Thalamic control of sensory selection in divided attention”. Nature Oct, 2015. doi: 10.1038/nature15398
