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Optical Neuroscience

Research tools for

calcium imaging and optogenetics

What is LUX?

LUX is the next generation of research tools for calcium-imaging and optogenetics

Stimulating and recording with light has rapidly expanded the neuroscience toolkit. LUX incorporates calcium imaging and optical stimulation into a single, turn-key device.

Perform stand-alone fiber photometry experiments or easily expand to synchronize with behavior and electrophysiology. Record and stimulate from customized LEDs and precisely control your designed experiment.

 

Optical Neuroscience:

Calcium imaging and optogenetics have revolutionized how neuroscientists understand neural circuitry. Standard electrophysiology records from 10s to a few 100s of neurons with no specificity. With calcium imaging, you can record from 100s to 1000s of neurons, targeting a structure or functional pathway. With optogenetic stimulation, you can target specific neurons and structures without the potential devasting damage that electrical stimulation generates.

*Data courtesy of UCLA Miniscope – Miniaturized fluorescent microscopy of GCaMP neurons

Why TDT?

TDT’s engineering knowledge of real-time signal processing and 20+ years of electrophysiology expertise are the backbone for a new era in calcium-based and optogenetic neuroscience.

Turn-key Device:

TDT developed the first fiber photometry system that uses lock-in amplification for simultaneous multi-color signal detection. With this feature, researchers can easily view, acquire, and analyze GCaMP and other fiber photometry responses in real-time.

Expandability:

The LUX processors seamlessly incorporate calcium imaging and optogenetic stimulation with behavioral monitoring and classic electrophysiology. TDT’s focus on expandability and integration allows researchers to collect all their neuroscience data in one place.

Customer Support:

TDT also emphasizes user friendly interfaces and strong support to help researchers get experiments up and running faster.

Fiber photometry – RZ10x and RZ10

The RZ10x is TDT’s upgraded system for integrated fiber photometry. The processor includes integrated drivers and LUX LED sources and photosensors for GCaMP, dLight, RCaMP and other fluorophore recordings in multiple animal or sites. Incorporate simultaneous optogenetic stimulation from a wide selection of wavelengths to further probe complex neural circuits.

Synapse software simplifies hardware configuration and data acquisition with its user-friendly interface. View GCaMP evoked responses in real-time during free-moving behavior. You can also integrate behavioral codes from multiple operant boxes. Easily expand the TDT system by incorporating video tracking and multi-channel electrophysiology (up to 32 channels).