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512+ Channel Ephys

A Modular, High Channel-Count Neural Recording System

Overview

Need more data? This system puts 512 channels of broadband recording and real-time control at your fingertips. Every channel is simultaneously sampled and user-specific processing is performed on the fly. Rack mount your system in a cart for easy portability. Use any combination of headstages to match your electrode configurations. Are 512 channels still not enough? Easily scale your system by adding additional amplifiers to reach 1024 channels and beyond!

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Published research: Electrophysiology

The newest papers in Electrophysiology that used TDT systems.

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Advanced Science · 2026

Printing-Assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling

Spencer Ryan Moore, Naomi King, Aruã Clayton Da Silva, … Ivan R. Minev

The limitations of electrical neuromodulation are driving the development of neuroprosthetic systems enhanced with complementary modalities. A key technological challenge however remains the integration of the necessary hardware components (optical, thermal, fluidic, electrical) into miniaturized implants. Here we present a design framework, inspired by fast prototyping, that promises to reduce the complexity, fabrication time, and device bulk of multimodal neural interface systems. By combining extrusion‐based 3D printing of silicones and discrete electronic components, we integrated thermal neuromodulation and electrical recording capabilities in soft packages suitable for placement on the cortical surface of rodents. When linked to an autonomous auxiliary driver unit, these packages establish rapid, stable and localized hypothermia together with ElectroCorticoGraphy (ECoG) recording. In a rodent model of epilepsy (4‐aminopyridine), we demonstrate hypothermia‐induced suppression of seizure‐like activity. Our approach may advance the clinical translation of focal hypothermia as an alternative therapy for drug‐resistant focal epilepsies.

Read the paper → (Printing-Assisted Integration of Thermal, Fluidic and Electrical Components in Implants for Focal Brain Cooling, opens in a new tab)
bioRxiv · 2026

Active sensing movements by antennae enhance neural processing and plasticity for odour processing in the CNS in the honey bee Apis mellifera

Nisha Kulkarni, Harry H Lei, Jake Leyko, … Hong Lei

Animals frequently move their sensory organs relative to dynamic environmental stimuli to maximize information acquisition, a behaviour known as active sensing. Recent studies show that insects adjust antennal movements according to the temporal structure and salience of olfactory signals, suggesting that antennae participate in active sensing. However, how these movements affect central olfactory processing remains unclear. To address this question, we trained honey bee foragers using a proboscis extension response (PER) protocol in which one odour (CS+) was paired with sucrose and another (CS−) with salt water. This training produces distinct antennal movements toward the two odours. Bees were subsequently tested with a series of concentrations of both CS+ and CS− odours. Antennae were either fixed or allowed to move freely during training and testing, while electrophysiological recordings were made from the antennae and from the antennal lobes. Peripheral antennal responses across odour concentrations were not affected by whether the antennae were fixed or free. In contrast, antennal lobe projection neurons and local interneurons showed learning-related increases in responses to the CS+ odour, consistent with previous studies, and these increases were stronger in bees with freely moving antennae. Neural responses were also more variable, particularly at lower odour concentrations, when antennae could move, suggesting that response variability may contribute to plasticity. These results support the hypothesis that active antennal movements influence central processing of odour representations. Future studies comparing restrained bees with freely walking bees will help clarify the natural behavioural contexts in which antennal movements enhance olfactory sensing. SUMMARY STATEMENT This study shows that allowing honey bees to move their antennae enhances learning-related neural plasticity, linking active sensing behaviour to central olfactory processing.

Read the paper → (Active sensing movements by antennae enhance neural processing and plasticity for odour processing in the CNS in the honey bee Apis mellifera, opens in a new tab)
bioRxiv · 2026

A Novel Cortico-Striatal NREM Sleep Rhythm in Mice and Non-Human Primates

Aviv D. Mizrahi-Kliger, Samantha Coury, Cameron L. Woodard, Karunesh Ganguly

With practice, rapid early gains in performance are followed by a slower phase marked by kinematic refinement, automaticity and enhanced cortical and striatal interactions. While sleep is known to support early learning, its causal role in the slow phase of learning is not known. Here we recorded neuronal activity in primary motor cortex (M1) and the dorsolateral striatum (DLS) during long-term skill acquisition and interleaved sleep. Surprisingly, the slow phase of learning was marked by the emergence of a previously unrecognized 5–10 Hz oscillatory activity during NREM sleep that was coherent across M1 and DLS. This oscillation resulted in repeated joint reactivation of task-specific information in cortex and striatum. Strikingly, during later stages of training, such joint reactivation of task activity increased over the course of NREM sleep, suggesting that sleep-dependent processing strengthens cortico-striatal interactions. The strength of M1–DLS coherence was predictive of next-day performance gains and increased cortico-striatal coupling during task performance. Targeted closed-loop disruption of this oscillation during NREM sleep abolished performance gains, whereas switching to a dose-matched random stimulation paradigm enabled performance improvements in the same animals. Importantly, the same cortico-striatal 5–10 Hz rhythm was also found in sleeping non-human primates, where it was selectively enhanced following learning. Together, we identify, across species, a novel NREM sleep oscillation that is important for sleep-dependent performance gains which depend on cortico-striatal processing.

Read the paper → (A Novel Cortico-Striatal NREM Sleep Rhythm in Mice and Non-Human Primates, opens in a new tab)

The WS-8 Workstation: Built for Compatibility

Finally, a computer as powerful as your TDT equipment. The WS-8 has been custom built with rapid system booting, removable data storage and an exceptional graphics card. The icing on the cake? The WS-8 is rack-mountable to minimize your system footprint.

*Also available with 4 Core, ask about the WS-4.

WS-8 Workstation

Powerful Data Analysis with Synapse Software

Enhance your software functionality with these extensions:

  • Animate playback of stored data for dynamic visualization of neural activity
  • Select and sort data on the fly during acquisition
  • Take control of data analysis using semi-automated or completely manual sorting modes

 

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