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ABR and DPOAE System

Simultaneous Auditory Stimulation and Recording

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Publications

This robust auditory research system gets things done. The versatile RZ6 Auditory Processor can provide complex auditory stimulation or reliable animal screening, day after day. High bandwidth provides a dynamic range of up to 115 dB and sampling rates up to ~200 kHz. Built-in attenuators, speaker and microphone amplifiers and even a monitor speaker greatly simplify setup and reduces both the overall footprint of the system and the number of cords needed. The RZ6 quickly connects to the MedusaZ amplifier for low-noise recordings. The power of the RZ6, combined with flexible input/output capabilities, make it ideal for pre-clinical auditory research experiments, from psychoacoustics to rapid phenotyping of deafness models.

Coupled with our proven BioSigRZ software, the Auditory Workstation is well-suited for Auditory Brainstem Response (ABR) screening, evoked potential research, and Distortion Product Otoacoustic Emissions (DPOAE) testing. The BioSigRZ protocol can be set once then effortlessly handed-off to technicians for routine testing. Our proven BioSigRZ signal averaging software includes standard experiments to get you started and provides enough flexibility to grow with your lab.

Rybalko … Syka, et al “Behavioral evaluation of auditory function abnormalities in adult rats with normal hearing thresholds that were exposed to noise during early development”. Physiology & Behavior Oct, 2019. doi: 10.1016/j.physbeh.2019.112620

Burghard … Oliver, et al “Mice heterozygous for the Cdh23/Ahl1 mutation show age-related deficits in auditory temporal processing”. Neurobiology of Aging Sep, 2019. doi: 10.1016/j.neurobiolaging.2019.02.029

Voigt … Esser, et al “The in-air auditory thresholds of the eurasian otter (Lutra lutra, L. 1758) as determined by auditory brainstem responses”. Hearing Research Sep, 2019. doi: 10.1016/j.heares.2019.107774

Hayes … Salvi, et al “Noise-induced hearing loss alters hippocampal glucocorticoid receptor expression in rats”. Hearing Research Aug, 2019. doi: 10.1016/j.heares.2019.04.013

Cederholm … Housley, et al “Onset kinetics of noise-induced purinergic adaptation of the ‘cochlear amplifier'”. Purinergic Signalling Aug, 2019. doi: 10.1007/s11302-019-09648-3

Zhang … Zou, et al “The TLR-4/NF-$ąppa$B signaling pathway activation in cochlear inflammation of rats with noise-induced hearing loss”. Hearing Research Aug, 2019. doi: 10.1016/j.heares.2019.04.012

Cederroth … Canlon, et al “Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids”. Current Biology Aug, 2019. doi: 10.1016/j.cub.2019.06.057

Fischl … Kopp‐Scheinpflug, et al “Urocortin 3 signalling in the auditory brainstem aids recovery of hearing after reversible noise‐induced threshold shift”. The Journal of Physiology Jul, 2019. doi: 10.1113/jp278132

Shi … Dai, et al “Feasibility of direct promontory stimulation by bone conduction: A preliminary study of frequency-response characteristics in cats”. Hearing Research Jul, 2019. doi: 10.1016/j.heares.2019.01.013

Dong … Jung, et al “Distortion product otoacoustic emissions: Sensitive measures of tympanic -membrane perforation and healing processes in a gerbil model”. Hearing Research Jul, 2019. doi: 10.1016/j.heares.2019.01.015

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Software Brings All the Features You Need:

BioSigRZ, ABR & DPOE Screening

  • Full signal averaging and analysis capabilities
  • Real-time visualization of averaged waveforms
  • Real-time speaker normalization
  • Artifact rejection
  • Peak, latency and comparison overlay analysis
  • Auto-cursoring and data manipulation
  • Easy configuration for rapid animal screening and hearing screening

BioSigRZ is an easy-to-use tool designed for rapid animal screening.

BioSigRZ automates presentation of auditory stimuli and acquisition of ABR and DPOAE responses. BioSigRZ let’s you design stimuli or use pre-set templates, and you can adjust auditory parameters on the fly. BioSigRZ is compatible with the RZ6 Multi I/O processor.

See More About BioSigRZ