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Electrical Stim System

Description

Publications

This system does double-duty in your lab. The RZ5D Processor, SIM Subject Interface Module, and ACO32 motorized commutator serve to acquire, process and analyze neural spikes from awake, behaving subjects. Use it to receive real-time updates from your behavioral control boxes (such as Med Associates, Lafayette, and Coulbourn) and smoothly integrate neural and behavioral data in a single data file. All events are timestamped and recorded for easy offline analysis.

The addition of the Subject Interface supports electrical stimulation and closed loop protocols. The RZ5Ds many I/O options give you the flexibility to trigger stimulation based on external events or control behavioral devices such as pellet feeders, liquid dispensers, or shockers. This system delivers the full benefit of the System 3 line of processors.

Caldwell … Ojemann, et al “Direct stimulation of somatosensory cortex results in slower reaction times compared to peripheral touch in humans”. Scientific Reports Dec, 2019. doi: 10.1038/s41598-019-38619-2

Bong … Suminski, et al “Flexible, multichannel cuff electrode for selective electrical stimulation of the mouse trigeminal nerve”. Biosensors and Bioelectronics Oct, 2019. doi: 10.1016/j.bios.2019.111493

Dirr … Otto, et al “Targeted Vagus Nerve Stimulation does not Disrupt Cardiac Function in the Diabetic Rat”. 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) July, 2019. doi: 10.1109/EMBC.2019.8857474

Michelson … Kozai, et al “Calcium activation of cortical neurons by continuous electrical stimulation: Frequency dependence, temporal fidelity, and activation density”. J. Neurosci. Res. 2019. doi: 10.1002/jnr.24370

Formento … Courtine, et al “Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury”. Nature Neuroscience Oct, 2018. doi: 10.1038/s41593-018-0262-6

Meng … Kameneva, et al “Upper stimulation threshold for retinal ganglion cell activation”. Journal of Neural Engineering Aug, 2018. doi: 10.1088/1741-2552/aabb7d

Delgado … Otto, et al “Effect of Asymmetric, Charge Balanced Stimuli on Elicited Compound Neural Action Potentials”. 40th Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. July, 2018. doi: 10.1109/EMBC.2018.8513057

Kotsakidis … Kameneva, et al “In vitro assessment of the differences in retinal ganglion cell responses to intra- and extracellular electrical stimulation”. Journal of Neural Engineering Jun, 2018. doi: 10.1088/1741-2552/aac2f7

Guo … Lim, et al “Ultrasound Produces Extensive Brain Activation via a Cochlear Pathway”. Neuron Jun, 2018. doi: 10.1016/j.neuron.2018.04.036

Spencer … Shivdasani, et al “Creating virtual electrodes with 2D current steering”. Journal of Neural Engineering Mar, 2018. doi: 10.1088/1741-2552/aab1b8

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Experimental Control and Design with Synapse Software

Spike detection and LFP analysis

 

Synapse provides function specific Gizmos and experiment templates to automate all but the highest level design steps.

 

Synapse Software interface

 

A streamlined software interface automates DSP level programming to bring speed and ease to complex experiment design tasks.

Synapse Suite

 

User Configurable RPvdsEX

 

Create your own User Gizmos, using RPvdsEx, for custom processing or signal averaging.