Optogenetics + Behavioral Neuroscience

CLOSED-LOOP STIMULATION WITH TDT’S REAL-TIME PROCESSOR

Description

Publications

The RZ10X processor is an all-in-one solution for behavioral neuroscience. Easily combine optogenetic stimulation and electrophysiology with precise closed-loop control. Stimulate with integrated LUX LEDs or trigger external light sources while simultaneously recording in real-time.

TDT’s Synapse software simplifies the design of a closed-loop system. For example, trigger optogenetic stimulation in response to:

detected seizure events
increased gamma or theta oscillation
changing firing patterns of a neuron
and more!

Michoud … Lacour, et al “Optical cuff for optogenetic control of the peripheral nervous system.” J Neural Eng. Feb, 2018. doi: 10.1088/1741-2552/aa9126.

Yazdan-Shahmorad … Sabes, et al “A Large-Scale Interface for Optogenetic Stimulation and Recording in Nonhuman Primates.” Neuron. Mar, 2016. doi: 10.1016/j.neuron.2016.01.013.

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SYNCHRONIZE STIMULATION WITH TDT'S REAL-TIME PROCESSOR

The RZ10X has integrated LUX LEDs for optogenetic stimulation (LED driving current: 1 – 1000 mA). Precisely control all stimulation parameters in Synapse, such as the number of pulses, frequency, and amplitude.

Simultaneously record electrophysiology with the PZ5 amplifier while stimulating for online evoked responses.

SYNAPSE: OPTOGENETICS AND CLOSED-LOOP CONTROL

Digital outputs can be triggered by events from any biological signal. For example, simply configure Synapse to detect spiking events (PCA spike sorting) to control the output of the Pulse Generator Gizmo. Pulses generated by the PulseGen Gizmo can be used in turn to drive the cycling of an optogenetic laser, grab frames from a behavioral camera, or other such experiments where time synchronization is critical.