New Frontiers in Neuroscience

Tucker-Davis Technologies

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PZ5 NeuroDigitizer

The Industry's First Multi-Modal Amplifier

The PZ5 NeuroDigitizer expands upon the capabilities of TDT’s previous amplifiers to deliver the best neurological signal capture available today.   With this multi-modal neurodigitizer, researchers can now capture any biological potential and artifacts without signal clipping, while simultaneously recording from different subjects and input types.  The PZ5 records across a broad signal range with no phase distortion.


Recent collaborations have led to non-ferrous headstage developments that now make it possible to record single unit electrophysiologys simultaneously during fMRI imaging. This cutting edge development makes PZ5 an ideal tool for correlating BOLD changes with underlying neural activity.

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Research Applications

  • Human & non human EEG
  • Multi-modal signal integration
  • Simultaneous animal recording
  • Sleep research
  • True Differential EMG
  • Record single unit and fMRI data  simultaneously



RZ2 BioAmp Processor

Real-time processing and programmable control of PZ5 modes and digital filtering.

ZIF-Clip® Headstages

Easily connect your implanted electrodes with TDT's zero-insertion force ZIF-Clip®  headstages.

RS4 Data Streamer

Improve real-time performance by storing data streamed from the RZ2 to the RS4.

Streamline Data Collection

Achieve the synchronized capture of single unit (neuron) recordings, evoked potentials, EMG, EEG and analog signals with the use of a single amplifier.  Recorded signals are amplified and digitized on the battery powered PZ5 and then transmitted to the RZ base station for further processing via an isolated, noiseless fiber optic connection. Researchers can monitor signal acquisition and make adjustments on the fly.


  • DC coupled to improve low frequency performance
  • Captures any potential and artifacts without clipping
  • Quick access to real-time configuration options
  • Simplifies configuration with visual interface and data preview right on the device
  • Highly portable, light-weight design

Versatile, Configurable Design

The PZ5 allows you to configure all aspects of your recording parameters, such as filter settings, sample rates and input type.  The isolated 16-channel banks are individually configurable with gain and sample rates optimized for intended neural input. The PZ5 is available in 32, 64, 96 or 128 channel models and supports sampling rates up to ~50 kHz.

Spikes + fMRI

Record single-unit electrophysiology simultaneously during fMRI imaging. Directly measure the correlation of individual neural activity with the hemodynamic response in the brains of awake, behaving subjects. Working closely with scientists in the field, TDT engineers helped enable this breakthrough by utilizing several unique features of the industry leading PZ5.


  • Connects via MRI patch panel with filters to reduce RF interference
  • Analyze brain function in awake, behaving subjects
  • fMRI compatible (non-ferrous) TDT headstages minimize imaging artifacts
  • Battery-powered & optically isolated amplifier

Pushing the Edge in the Field of High Channel Count Neurophysiology

At TDT, we understand that high fidelity data collection depends on fully integrated systems that combine multiple levels of optical isolation and noise-reducing battery powered amplifiers with dedicated digital signal processors (DSPs), capable of processing high-speed neural signals in real-time.


TDT’s PZ5 combines exceptional performance and unprecedented versatility to deliver the absolute best neurological signal capture available today. This next generation, multi-modal neurodigitizer functions as the front end for TDT’s popular RZ system, serving as a high performance option for new customers or a direct upgrade path for customers currently using earlier PZ amplifiers.


Easily connect multiple TDT RZ devices for higher channel counts. Both the PZ5 and PZ5M feature individually configurable banks for flexible experiment design.

- Prof. Dr. Pascal Fries, Director,

Ernst Strüngmann Institute (ESI) for Neuroscience

“I have never seen LFPs that clean with regard to line noise.”

*photo from Frankfurt Institute for Advanced Studies

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“I have never seen LFPs that clean with regard to line noise.”